![]() ![]() According to the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in adults, metabolic syndrome is defined by the presence of abdominal obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol levels, hypertension, and impaired fasting glycemia. Modern lifestyle increases the risk for chronic diseases such as metabolic syndrome. Sedentary behavior and an unhealthy diet are common in Western industrialized countries. International Registered Report Identifier (IRRID): RR2-10.2196/resprot.8607 Trial Registration: NCT02526732 (Archived by WebCite at ) In terms of future treatment strategies, NAFLD patients with high body fat may particularly benefit from body-fat reduction through a strict nutritional intervention, subsequently enabling a more effective exercise intervention. Patients with low body fat and low VO 2peak benefited the most from our intervention. The VO 2peak increased significantly by 2.4 mL/kg/min (8.8% 95% confidence interval : 1.48-3.27 P40% reduction in the average fat mass would be required to achieve an average outcome.Ĭonclusions: This is the first study to show that patients with NAFLD can be effectively supported by a Web-based approach, which can increase the VO 2peak to a similar extent as face-to-face interventions. Results: A total of 43 patients completed the intervention with no adverse events. The VO 2peak was assessed at baseline and at the end of the study by spiroergometry. Exercise progression was based on an a priori algorithm that considered the subjective rate for both perceived exhaustion and general physical discomfort. Regular individual patient feedback was provided to systematically adapt the weekly exercise schedule, which allowed us to monitor and ensure patient adherence to strength and endurance training and optimize the step-wise progressive exercise load. After a medical examination and performance diagnostics, a sports therapist introduced the patients to a Web-based platform for individualized training support. ![]() Methods: In a 24-month period, 44 patients were enrolled into an 8-week, prospective, single-arm study with 12 weeks of follow-up. Objective: We aimed to assess the effectiveness of an 8-week, tailored, Web-based exercise intervention for cardiorespiratory fitness improvement, expressed as peak oxygen uptake (peak volume of oxygen ), in patients with histologically confirmed NAFLD. We designed an eHealth approach for patients with NAFLD to improve the cardiorespiratory fitness and report the first results of the HELP (Hepatic Inflammation and Physical Performance in Patients With NASH ) study. Achievement of minimally effective physical activity to improve cardiorespiratory fitness among patients typically involves high personal and financial expenses in face-to-face settings. Exercise-based prevention interventions for improving cardiorespiratory fitness are a recommended complementary treatment for NAFLD. Asian/Pacific Island Nursing Journal 10 articlesĭepartment of Sports Medicine, Disease Prevention and RehabilitationĮmail: Physical inactivity is a major risk factor for nonalcoholic fatty liver disease (NAFLD).JMIR Bioinformatics and Biotechnology 32 articles.JMIR Biomedical Engineering 68 articles.Journal of Participatory Medicine 78 articles.JMIR Perioperative Medicine 89 articles.JMIR Rehabilitation and Assistive Technologies 201 articles.JMIR Pediatrics and Parenting 279 articles.Interactive Journal of Medical Research 306 articles.JMIR Public Health and Surveillance 1141 articles.Journal of Medical Internet Research 7471 articles. ![]()
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